logo

Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects

PDF Publication Title:

Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects ( polyphenols-extraction-methods-antioxidative-action-bioavail )

Next Page View | Return to Search List

Text from PDF Page: 001

molecules Review Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects Eva Brglez Mojzer 1,†, Maša Knez Hrncˇicˇ 2,†, Mojca Škerget 2, Željko Knez 2,* and Urban Bren 1,* 1 2 * † Laboratory of Physical Chemistry and Chemical Thermodynamics, Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, SI-2000 Maribor, Slovenia; eva.spaninger@um.si Laboratory of Separation Processes and Product Design, Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, SI-2000 Maribor, Slovenia; masa.knez@um.si (M.K.H.); mojca.skerget@um.si (M.Š.) Correspondence: zeljko.knez@um.si (Ž.K.); urban.bren@um.si (U.B.); Tel.: +386-2-2294-431 (Ž.K.); +386-2-2294-421 (U.B.) These authors contributed equally to this work. Academic Editor: Pedro Mena Received: 31 May 2016; Accepted: 5 July 2016; Published: 11 July 2016 Abstract: Being secondary plant metabolites, polyphenols represent a large and diverse group of substances abundantly present in a majority of fruits, herbs and vegetables. The current contribution is focused on their bioavailability, antioxidative and anticarcinogenic properties. An overview of extraction methods is also given, with supercritical fluid extraction highlighted as a promising eco-friendly alternative providing exceptional separation and protection from degradation of unstable polyphenols. The protective role of polyphenols against reactive oxygen and nitrogen species, UV light, plant pathogens, parasites and predators results in several beneficial biological activities giving rise to prophylaxis or possibly even to a cure for several prevailing human diseases, especially various cancer types. Omnipresence, specificity of the response and the absence of or low toxicity are crucial advantages of polyphenols as anticancer agents. The main problem represents their low bioavailability and rapid metabolism. One of the promising solutions lies in nanoformulation of polyphenols that prevents their degradation and thus enables significantly higher concentrations to reach the target cells. Another, more practiced, solution is the use of mixtures of various polyphenols that bring synergistic effects, resulting in lowering of the required therapeutic dose and in multitargeted action. The combination of polyphenols with existing drugs and therapies also shows promising results and significantly reduces their toxicity. Keywords: polyphenols; extraction; antioxidants; cancer; bioavailability; synergistic effects 1. Introduction Nowadays nutrition is gaining importance as the basic foods are processed in a way whereby organoleptic properties prevail over their nutrient composition. That is the main reason behind the widespread obesity problem and also for the appearance of several currently prevailing diseases. Studies have shown that correct dietary habits, including consumption of plenty and various fruits, legumes and grains can prevent 10%–70% of cancer deaths [1]. However, the substances in listed foods that mainly contribute to disease prevention and healing have only been discovered not so long ago [2]. These highly important substances are polyphenols, some of which exert even higher antioxidant action than vitamins [2,3]. The polyphenols represent a large group of at least 10,000 different compounds that contain one or more aromatic rings with one or more hydroxyl groups attached to them [4,5]. As secondary plant metabolites they are abundant in the majority of fruits and vegetables [5]. The most commonly Molecules 2016, 21, 901; doi:10.3390/molecules21070901 www.mdpi.com/journal/molecules

PDF Image | Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects

polyphenols-extraction-methods-antioxidative-action-bioavail-001

PDF Search Title:

Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects

Original File Name Searched:

molecules-21-00901.pdf

DIY PDF Search: Google It | Yahoo | Bing

Molecular Hydrogen: Clinically researched and proven as a antioxidant and more... More Info

Molecular Hydrogen Machine: Cart mounted molecular hydrogen machine for infusing antioxidant hydrogen into oils and making high value skin creams... More Info

Infinity Supercritical 10L CO2 Extractor: Supercritical CO2 Hemp Oil Extraction for Full Spectrum Botanical Oil which retains the terpenes and other valuable plant components during extraction. System runs silent with small footprint of 24 inches by 48 inches... More Info

Infinity Supercritical has developed the most profitable Supercritical CO2 Extraction Machines. Our CO2 terpene extraction system rapidly produces shelf-ready oils which make more money. Perfect for hemp oil extraction using environmentally friendly CO2 extraction equipment. Manufactures efficient oil extraction systems and machines for natural terpenes, flavorings, fragrance, hemp, beer hops, lavender and other botanicals. New for 2021 includes Molecular Hydrogen Skin Cream Machine for production of high value cosmetic skin cream. Silent technology includes supercritical co2, oil-to-oil extraction using induction magnetic mixing, and eco friendly hydrodynamic cavitation water as the solvent in our closed-looped systems. The process can also be used for electrowinning, e-waste recycling, and lithium battery recycling, gold mining electronic wastes, precious metals. CO2 can also be used in a reverse fuel cell with nafion to make a gas-to-liquids fuel, such as methanol, ethanol and butanol or ethylene. Supercritical CO2 has also been used for treating nafion to make it more effective catalyst. SCO2 can remove water from wood as an alternative to conventional kiln drying.

CONTACT TEL: 608-238-6001 Email: greg@infinitysupercritical.com | RSS | AMP