Molecular hydrogen: a therapeutic antioxidant and beyond

PDF Publication Title:

Molecular hydrogen: a therapeutic antioxidant and beyond ( molecular-hydrogen-therapeutic-antioxidant-and-beyond )

Next Page View | Return to Search List

Text from PDF Page: 001

REVIEW Molecular hydrogen: a therapeutic antioxidant and beyond Lei Huang1, 2, * 1 Department of Anesthesiology, Loma Linda University, Loma Linda, CA, USA 2 Department of Basic Sciences, Division of Physiology, Loma Linda University, Loma Linda, CA, USA *Correspondence to: Lei Huang, M.D., lhuang@llu.edu. orcid: 0000-0002-7211-8337 Molecular hydrogen (H2) medicine research has flourished since a landmark publication in Nature Medicine that revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Emerging evidence has consistently demonstrated that molecular hydrogen is a promising therapeutic option for a variety of diseases and the underlying comprehensive mechanisms is beyond pure hydroxyl radicals scavenging. The non-toxicity at high concentrations and rapid cellular diffusion features of molecular hydrogen ensure the feasibility and readiness of its clinical translation to human patients. Key words: hydrogen-saturated water/saline; hydrogen gas; free radical scavenger; anti-inflammation; anti-apoptosis; biological effect; clinical application; hydrogen-oxygen nebulizer machine doi: 10.4103/2045-9912.196904 How to cite this article: Huang L (2016) Molecular hydrogen: a therapeutic antioxidant and beyond. Med Gas Res 6(4):219-222. Open access statement: This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial- ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. Abstract IntroductIon Molecular hydrogen (H2), the most lightweight gas, is routinely used as a component of exotic breathing gas mixture, namely hydreliox (49% H2, 50% helium and 1% O2) for deep water divers to prevent decompression sickness (Abraini et al., 1994; Ohta, 2011). Therapeutic application of H2 as a free radical catalyzer debuted in 1970s. A 2-week treatment of hyperbaric 97.5% H2 gas in the absence of explosion risk caused a significant regression of skin tumor or leukemia in animals (Dole et al., 1975; Roberts et al., 1978). It was pospulated that the underlying mechansim was through hydroxyl radicals scanverging by exthermic reaction of H2 + ·OH = H2O + H· followed by H· + O2– = HO2– reaction (Dole et al., 1975). In 2001, Gharib et al. (2001) confirmed the similar treatment efficacy of hyperbaric hydrogen aganist parasite-induced mice liver inflammation, consistently suggesting the protective mechanism at least in part by the reaction of molecular hydrogen with hydroxyl radicals. Five years later, Ohsawa et al. (2007) intensively eluic- dated the seletive antioxidant feature of normobaric 2% H2 gas (below the 4% explosion level) and its cytoprotec- tive benefit against reperfusion oxidative injury using cell culture in vitro and a rat model of focal stroke in vivo. The finding added hydrogen as an innovative approach into a collection of therapeutic strategies against stroke (Dock et al., 2015; Li et al., 2015; Lioutas et al., 2015; Merali et al., 2015; Pena and Borlongan, 2015; Ploughman et al., 2015; Qi et al., 2015; Reuter et al., 2015; Schlunk et al., 2015; Soliman et al., 2015; Zhu et al., 2015). The antioxidant advantages of H2 gas included: 1) its high biomembrane penetration and intracellular diffusion capability which enable it to reach subcellular compart- ments like mitochondria; and 2) selectively scavenging the deleterious hydroxyl radical while preserving other important reactive oxygen and nitrogen species for normal signaling regulation. It is superior to some antioxidant supplements with strong reductive activity such as vitamin C or vitamin E to avoid the increased risk of mortality (Ohsawa et al., 2007). Since this landmark publication © 2016 Medical Gas Research | Published by Wolters Kluwer - Medknow 219

PDF Image | Molecular hydrogen: a therapeutic antioxidant and beyond


PDF Search Title:

Molecular hydrogen: a therapeutic antioxidant and beyond

Original File Name Searched:


DIY PDF Search: Google It | Yahoo | Bing

Molecular Hydrogen: Clinically researched and proven as a antioxidant and more... More Info

Molecular Hydrogen Machine: Cart mounted molecular hydrogen machine for infusing antioxidant hydrogen into oils and making high value skin creams... More Info

Infinity Supercritical 10L CO2 Extractor: Supercritical CO2 Hemp Oil Extraction for Full Spectrum Botanical Oil which retains the terpenes and other valuable plant components during extraction. System runs silent with small footprint of 24 inches by 48 inches... More Info

Infinity Supercritical has developed the most profitable Supercritical CO2 Extraction Machines. Our CO2 terpene extraction system rapidly produces shelf-ready oils which make more money. Perfect for hemp oil extraction using environmentally friendly CO2 extraction equipment. Manufactures efficient oil extraction systems and machines for natural terpenes, flavorings, fragrance, hemp, beer hops, lavender and other botanicals. New for 2021 includes Molecular Hydrogen Skin Cream Machine for production of high value cosmetic skin cream. Silent technology includes supercritical co2, oil-to-oil extraction using induction magnetic mixing, and eco friendly hydrodynamic cavitation water as the solvent in our closed-looped systems. The process can also be used for electrowinning, e-waste recycling, and lithium battery recycling, gold mining electronic wastes, precious metals. CO2 can also be used in a reverse fuel cell with nafion to make a gas-to-liquids fuel, such as methanol, ethanol and butanol or ethylene. Supercritical CO2 has also been used for treating nafion to make it more effective catalyst. SCO2 can remove water from wood as an alternative to conventional kiln drying.

CONTACT TEL: 608-238-6001 Email: greg@infinitysupercritical.com | RSS | AMP