Molecular Hydrogen protective against mild oxidative stress

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Molecular Hydrogen protective against mild oxidative stress ( molecular-hydrogen-protective-against-mild-oxidative-stress )

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Availability: OTC as hydrogen-rich water Dose: 1-3 ppm H2 water (drink) daily 1-3% H2 gas (inhalation) (in surgical setting). Based on clinical trials. Chemical formula: H2 MW: 2.016 g/mol Source: Pubchem Half-life: ~2 hours after exposure to air (H2 water) BBB: Penetrant Clinical trials: Parkinson’s disease (n=18, 178), MCI (n=73), stroke (n=34, 38, 50), metabolic disorders (n=10, 20, 30, 68), UV-skin damage (n=6, 11), myopathy (n=12, 10), inflammatory autoimmune disease (n=20, 75) , chemoprotection (n=136), hepatitis (n=60) Observational studies: One study (n=309) revealed benefits in dialysis patients. What is it? Molecular hydrogen is a gas which can be used therapeutically to help prevent oxidative stress damage. Molecular hydrogen can be inhaled as a gas at concentrations of 1-3% (plus 20-30% oxygen, and nitrogen making up the remainder) or it can be dissolved into water or saline under pressure to create saturated (1.6 mg/L= 1.6 ppm= 0.8 mM) and supersaturated solutions (>1.6 ppm) [1]. Hydrogen gas inhalation has been tested for the mitigation of acute neurological impairment associated with stroke/heart attack or surgery. Hydrogen-rich water has been used to protect against oxidative stress and inflammation in a variety of conditions, including Parkinson’s disease, diabetes and metabolic dysregulation, kidney disease, hepatitis rheumatoid arthritis, and chemotherapy. Hydrogen water bathing is also popular in Japan for the maintenance of youthful skin and preventing wrinkles. Molecular hydrogen acts as an antioxidant to reduce hydroxyl radicals and peroxynitrite (ONOO-), but does not neutralize potentially beneficial free radicals, such as nitric oxide. Hydrogen can also modulate miRNA expression and signal transduction pathways [2]. Some of the protective benefits appear to be related to induction of the Nrf2 antioxidant pathway and the fatty acid metabolism regulator FGF21. However, the exact mechanisms mediating its beneficial effects are not fully understood. 2

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