hydrogen-rich water for improvements of mood, anxiety, nerve function

PDF Publication Title:

hydrogen-rich water for improvements of mood, anxiety, nerve function ( hydrogen-rich-water-improvements-mood-anxiety-nerve-function )

Previous Page View | Next Page View | Return to Search List

Text from PDF Page: 002

brain and body indicates actions both in the central and peripheral nervous systems. Previous clinical studies have shown that hydrogen-rich water (HRW) reduces concentrations of markers of oxidative stress in patients with metabolic syndrome,5,6 improves lipid and glucose metabolism in patients with type 2 diabetes,7 improves mitochondrial dysfunction in patients with mitochon- drial myopathies, and reduces inflammatory processes in patients with polymyositis/dermatomyositis.8 In an- other study, exercise-induced declines in muscle function among elite athletes were also improved by administering HRW.9 Although such findings suggest that HRW may help alleviate symptoms of several diseases and increase the physical performance of athletes, the effects of pro- longed HRW ingestion on the QOL of individuals in the general population remain unknown. Some reports have demonstrated that oxidative stress is associated with QOL in patients with chronic obstruc- tive pulmonary disease and cervical cancer.10,11 During oncological treatment among patients with cervical cancer, antioxidant supplementation was found to be effective in improving QOL.11 In addition, Kang et al.12 reported that treatment with HRW for patients receiving radiotherapy for liver tumors decreased oxidative stress and improved QOL. Although the association between oxidative stress and QOL in healthy individuals is still unclear, aging, job stress, and cognitive load over the course of several hours in healthy individuals have also been found to induce increases in oxidative stress,13-16 suggesting that preventing the accumulation of oxida- tive stress caused by daily stress and daily work may contribute to the maintenance of QOL and amelioration of the effects of aging. Continuous HRW intake might therefore be expected to reduce accumulation of oxida- tive stress, thus helping to prevent decreases in QOL. The aim of the present study was to investigate the effects of drinking 600 mL of HRW per day for 4 weeks on the QOL of adult volunteers using questionnaires for sleep, fatigue, mood, anxiety, and depression, an autonomic function test, and a higher cognitive function test. subjects and Methods subjects Thirty-one adult volunteers between 20 and 49 years old participated in this double-blinded, randomized, placebo- controlled study with a two-way crossover design. Exclu- sion criteria comprised: history of chronic illness; chronic medication or use of supplemental vitamins; employment in shift work; pregnancy; body mass index ≤ 17 or ≥ 29 kg/m2; food allergy; history of smoking; or history of drinking excessive amounts of alcohol (≥ 60 g/day). Shift workers were excluded because the water was administered at breakfast and dinner, the timings of which are irregular among shift workers. In addition, the mental and physical conditions of shift workers can be greatly affected by the shift schedule for the preceding 2 days, which may impact the results obtained from the questionnaires used in this study. Before each experiment, participants were asked to refrain from drinking alcohol, since drinking excessive amounts of alcohol carries significant risks of fluctuations in physical condition. All experiments were conducted in compliance with national legislation and the Code of Ethical Principles for Medical Research Involving Human Subjects of the World Medical Association (the Declaration of Hel- sinki) and registered to the UMIN Clinical Trials Registry (No. UMIN000022382). The study protocol was approved by the Ethics Committee of Osaka City University Center for Health Science Innovation (OCU-CHSI-IRB No. 4), and all participants provided written informed consent for participation in the study. study design We used a double-blinded, placebo-controlled study with a two-way crossover design, as summarized in Figure 1. After admission to the study, participants were randomized in a double-blinded manner to receive HRW in an aluminum pouch (0.8–1.2 ppm of hydrogen, 300 mL/pouch; Melodian Corporation, Yao, Japan) or placebo water (PLW), repre- senting mineral water from the same source (i.e., same components without hydrogen) in an aluminum pouch (0 ppm of hydrogen, 300 mL/pouch; Melodian Corpora- Figure 1: Time course of the experiments. Note: Participants were randomly divided into two study groups. The experiment consisted of 4 weeks of hydrogen-rich water (HRW) administration or placebo water (PLW) administration, a 4-week washout period, and then another 4 weeks of PLW administration or HRW administration. Before (pre) and after (post) each period of HRW or PLW administration, subjective and objective measurements for quality of life were obtained, such as results for sleep, mood, anxiety, feelings of depression, autonomic nerve function, and cognitive function. Mizuno et al. / Med Gas Res www.medgasres.com 248 Medical Gas Research ¦ December ¦ Volume 7 ¦ Issue 4

PDF Image | hydrogen-rich water for improvements of mood, anxiety, nerve function


PDF Search Title:

hydrogen-rich water for improvements of mood, anxiety, nerve function

Original File Name Searched:


DIY PDF Search: Google It | Yahoo | Bing

Molecular Hydrogen: Clinically researched and proven as a antioxidant and more... More Info

Molecular Hydrogen Machine: Cart mounted molecular hydrogen machine for infusing antioxidant hydrogen into oils and making high value skin creams... More Info

Infinity Supercritical 10L CO2 Extractor: Supercritical CO2 Hemp Oil Extraction for Full Spectrum Botanical Oil which retains the terpenes and other valuable plant components during extraction. System runs silent with small footprint of 24 inches by 48 inches... More Info

Infinity Supercritical has developed the most profitable Supercritical CO2 Extraction Machines. Our CO2 terpene extraction system rapidly produces shelf-ready oils which make more money. Perfect for hemp oil extraction using environmentally friendly CO2 extraction equipment. Manufactures efficient oil extraction systems and machines for natural terpenes, flavorings, fragrance, hemp, beer hops, lavender and other botanicals. New for 2021 includes Molecular Hydrogen Skin Cream Machine for production of high value cosmetic skin cream. Silent technology includes supercritical co2, oil-to-oil extraction using induction magnetic mixing, and eco friendly hydrodynamic cavitation water as the solvent in our closed-looped systems. The process can also be used for electrowinning, e-waste recycling, and lithium battery recycling, gold mining electronic wastes, precious metals. CO2 can also be used in a reverse fuel cell with nafion to make a gas-to-liquids fuel, such as methanol, ethanol and butanol or ethylene. Supercritical CO2 has also been used for treating nafion to make it more effective catalyst. SCO2 can remove water from wood as an alternative to conventional kiln drying.

CONTACT TEL: 608-238-6001 Email: greg@infinitysupercritical.com | RSS | AMP