Assessment of Hydrogen Peroxide as Used in Cosmetics

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Assessment of Hydrogen Peroxide as Used in Cosmetics ( assessment-hydrogen-peroxide-as-used-cosmetics )

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Distributed for Comment Only -- Do Not Cite or Quote To: From: [hydper062018rep] In June 2016, Hydrogen Peroxide was chosen as the hair dye ingredient to be reviewed for 2017. On April 13, 2018, CIR issued the Scientific Literature Review (SLR) for this ingredient with a request for any pertinent data. The Council has submitted concentration of use data. [hydper062018data] No other data have been submitted for this ingredient. Council comments have been addressed. [hydper062018pcpc] According to FDA’s VCRP [hydper062018FDA] and the Council survey, Hydrogen Peroxide is reported to be used in hair dyes up to 15% in a professional product (that is diluted for use) and at up to 12.4% in consumer hair dyes and colors formulations; Hydrogen Peroxide is reported to be used in a total of 250 hair-coloring formulations. Hydrogen Peroxide is also used in other categories of ingredients, including formulations that result in dermal leave-on exposure at up to 3% in the category of other shaving preparations. There are reported to be 93 formulations that come in contact with mucous membranes and may result in incidental ingestion, including at up to 4.6% in dentifrices. Also included in this packet are the flow chart [hydper062018flow], history [hydper062018hist], data profile [hydper062018prof], and search strategy [hydper062018strat]. If no further data are needed, the Panel should formulate a Discussion and issue a Tentative Report. However, if additional data are required, the Panel should be prepared to identify those needs and issue an Insufficient Data Announcement (IDA). __________________________________________________________________________________________ 1620 L Street, NW Suite 1200, Washington, DC 20036 (Main) 202-331-0651 (Fax) 202-331-0088 (Email) cirinfo@cir-safety.org (Website) www.cir-safety.org Date: Subject: Safety Assessment of Hydrogen Peroxide as Used in Cosmetics Enclosed is the Draft Report of the Safety Assessment of Hydrogen Peroxide as used in Cosmetics. Commitment & Credibility since 1976 MEMORANDUM CIR Expert Panel and Liaisons Lillian C. Becker, M.S. Scientific Analyst and Writer May 11, 2018

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