Microfluidizer Cannabis

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Application Note Use of MicrofluidizerTM technology for Cannabis Products 28 States in the United States and Washington DC have legalized medical marijuana, among those 8 States plus Washington DC have legalized marijuana for recreational use. In 2016 the revenue was ~ 6.7 billion. An increase of 30% in the next 4 years is forecasted. Possible up to 50% of products being legally sold are for oral consumption. Commonly referred to as “Edibles”, oral products have a lot of advantages over smoking. There are >700 strains of Cannabis, growers constantly come up with new strains, some of them take off and become recognizable, others disappear. Growers usually target certain characteristics when they combine 2 strains. There are about 111 cannabinoids. The two main ingredients are Tetrahydrocannabinol (THC) and Cannabidiol (CBD). THC produces the euphoric effect with some therapeutic benefits, CBD offers a wide range of proven medical benefits such as anti-inflammatory, anti-oxidant, anti-anxiety, etc. However, there’s a major challenge when formulating cannabis oil into consumable products. Cannabis oil has poor water solubility and low bioavailability. Bioavailability through smoking can vary between 2-56%. Direct oral administration of raw or un-encapsulated cannabis oil, e.g., eating a cookie, provides even lower bioavailability of only 6-20%. On top of this, the onset of the effect can be delayed as much as 60 minutes and it takes hours after digestion to reach peak effect. Why MicrofluidizerTM Technology The low bioavailability of cannabis oil can be overcome by formulating the products into nano- emulsions or encapsulations. It has been demonstrated that previ- ously mentioned bioavailability can be increased by multiple folds to 50-75% through nano-formulations. For edibles, the time required to respond to a recrea- tional edible is also reduced even at lower dosages. For CBD based creams and lotions, nanoemulsion formula- tions typically achieve same therapeutic effects at much lower dosage as a result of increased bioavailability. The adverse effect is also reduced with reduced dosage. When making a nanoemulsion, droplet size distribution, or polydispersity (PDI), is another important considera- tion in addition to the droplet size since it can greatly affect the stability of the nanoemulsion. High polydis- persity indicates existence of large droplets, which can destabilize the emulsion through phenomenon such as Ostwald ripening. Therefore, narrow size distribution is desired and often means longer product shelf life. Last but not least, when the droplet size drops below 100nm, nanoemulsions often become translucent or even transparent in appearance. This can be particular- ly beneficial in clear beverage applications. Microfluidizer technology is the only technology that can create nano-sized emulsions or encapsulations meet all above requirements. Unlike all other types of technologies, whether they be mixers or homogenizers, Microfluidizer processors provide highest uniform shear rates on the market by utilizing fixed geometry interac- tion chambers and extremely high constant processing pressures. Microfluidizer technology also guarantees scale up so that product processing and results are con- sistent from development to manufacturing. In addi- tion, Microfluidizer processors have a proven track of record with meeting all FDA requirements for food and pharmaceutical productions. For cannabis producers, extractors, and processors who need to improve their products, whether recreational (THC) or therapeutic (CBD), the Microfluidizer high- shear processors provide a scalable solution with the highest efficiency which will differentiate the products by improving shelf life, stability, and effectiveness with significantly less amount of expensive cannabis oil.

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