Cannabinol: degradation leads to opportunity

PDF Publication Title:

Cannabinol: degradation leads to opportunity ( cannabinol-degradation-leads-opportunity )

Next Page View | Return to Search List

Text from PDF Page: 001

Cannabinol: degradation leads to opportunity? Abdul R Mohammad, Sergio Pagliazzi Cannabinol (CBN) is the cannabinoid which is generally indicative of the age of the cannabis plant. This is because CBN is formed from degradation of THC on exposure to heat and UV light, and this conversion occurs over time-subject to storage conditions. As well being a degradation product of THC, it has also shown to be a rapid metabolite of THC in the blood (McCallum et al., 1975). Heat UV light Figure 4: The degradation of THC to CBN, which occurs in the presence of heat and UV light. The reaction is a partial hydrogenation of one of the aromatic rings of THC. CBN acts as a weak agonist to CB1 and CB2, about 4 times less potent at CB1 compared to THC (Rhee et al., 1997). CBN exhibited a much higher inhibitory constant (Ki) than THC (about 6 times higher) on brain CB1 receptors, indicated in brain synaptosomal binding experiments (Rhee et al., 1997). Hence it does not bind to CB1 with the same affinity as does THC. This could provide the explanation behind CBN’s minimal psychoactive effects. CBN is metabolised to 11-OH-CBN (via 11- hydroxylation), which is twice as potent as CBN on CB1 receptors but can only exhibit partial agonist activity at the CB2 receptor (Rhee et al., 1997). Even though it is more potent on brain CB1 receptors than CBN, it is still three times less potent than THC on these receptors (Rhee et al., 1997). It has shown to have less than 10% of the Psychoactive and cardio acceleratory effects of THC in humans (Howlett, 1987). In another study the effects of CBN were considered to be less intense (both physiologically and psychologically) in humans subjects compared with the effects of THC (Hiltunen and Järbe, 1986).

PDF Image | Cannabinol: degradation leads to opportunity


PDF Search Title:

Cannabinol: degradation leads to opportunity

Original File Name Searched:


DIY PDF Search: Google It | Yahoo | Bing

Infinity Supercritical 10L CO2 Extractor Supercritical CO2 Hemp Oil Extraction for Full Spectrum Botanical Oil which retains the terpenes and other valuable plant components during extraction. System runs silent with small footprint of 24 inches by 48 inches. More Info

$149,000 Complete CO2 Extraction System: Botanical full spectrum oil extraction. More Info

High Quality Full Spectrum Oil: More Info

Technology for Supercritical CO2 Extraction: More Info

CONTACT TEL: 608-238-6001 Email: greg@infinitysupercritical.com | RSS | AMP